Vash the Stampede, a legendary gunslinger fighting on a brutal desert planet, is intent on protecting humanity from his genocidal twin brother Knives when he ends up vanishing after a catastrophic battle. But when he wakes, he is a wandering pacifist again, and has yet to face the ruthless Gung-Ho Guns assassins. Using his god-tier gunmanship and hidden alien powers from his past, Vash recruits a rogue priest and insurance agents to save towns, defend plants, and survive it all. But will he be able to uphold his vow of mercy and stop his brother's march?